Focus on Zoé Jobert: Biotech engineering tackling rare diseases!

For this 3rd portrait in our series dedicated to the talents of NVDIAG LabCom, we introduce you to Zoé, a final-year student at SupBiotech, a leading biotechnology engineering school. Currently completing her end-of-studies internship, she brings her engineering perspective to a major challenge: the CD42a/CD42b project.

The Challenge: Bernard-Soulier Syndrome. This rare hematological disorder is linked to a defect in the GPIb-IX protein complex on the surface of platelets, leading to coagulation disorders. In partnership with BioCytex, Zoé is working on developing an innovative diagnostic kit through two complementary approaches:

• Producing the complex on extracellular vesicles (EVs) to generate nano-antibodies in their native conformation.
• Selecting nano-antibodies against soluble recombinant proteins.

On a daily basis, Zoé deploys the full technical arsenal acquired during her years at SupBiotech: phage display, Western Blot, ELISA, BLI (Bio-Layer Interferometry), and flow cytometry. She particularly enjoys managing a research project in its entirety, from experimental design to the analysis of results.

Supporting future engineers from SupBiotech in projects with high medical impact is a true source of pride for NVDIAG.

Well done, Zoé, for your expertise and commitment!