Participation in the #BioAnalytics2025 South EMEA User Group Meeting in Barcelona!

Last October, Alain Roussel had the pleasure of presenting our latest work on the characterization of complex molecular interactions.

The challenge: « Seeing » the infinitely small on giant structures

Characterizing the interaction kinetics between small Nanobodies (15 kDa) and Extracellular Vesicles (EVs) of 100 nm, which weigh several million Daltons, represents a significant technical challenge for Bio-Layer Interferometry (BLI).

Thanks to the increased sensitivity of the new Octet® R8e system, our teams have reached a decisive milestone:

• Unrivaled sensitivity: Detection of kinetic signals previously inaccessible, particularly for the #MUC1 and #CD38 projects.
• Native environment: Analysis of membrane proteins in their natural biological context, ensuring optimal stability and folding.
• Methodological innovation: Validation of an innovative « multi-layer » approach using an ALFA-tag anchor to stabilize vesicles on the sensors.

A big thank you to Sartorius for the invitation and the high-quality exchanges during this event!

Check out our poster here